Born in France, Jodorowsky is the son of Chilean Alejandro Jodorowsky and Mexican Valerie Trumblay, and is the brother to Brontis Jodorowsky. He has appeared in seven films to this day. As an actor, he won the Saturn Award for Best Performance by a Younger Actor in 1989 for his role as the Young Fenix in Santa Sangre, one of his father's more renowned films.
Jodorowsky started playing piano at the age of six. At the age of seven, he met James Brown at the backstage of a concert. Brown taught Adan how to dance like him. Jodorowsky's first guitar lessons were given by The Beatles guitarist George Harrison who was a friend of his parents. In this occasion Harrison told him that "he was far", Adan did not know if "he was far" in an enlightened way or "far" from being a good guitarist. When he was sixteen he joined the punk band The Hellboys, then he wanted to try another music genre and meet Yarol Poupaud and Adrienne Pauly, Following these encounters he started playing bass.
On October 30, 2006, he released his first solo album, Étoile Éternelle, as "Adanowsky", and his first single, L'idole (meaning "the idol") which was also released in Spanish as El Idolo; the song is about a waiter who wants all the attention and dreams of becoming famous and an idol.
In 2010 he helped on Alizée's new album, writing a song for her called La Candida. He has also composed works such as Echek (2000) and Teou (2001), as well as directing Echek, "Un Sol Con Corazón" and "El Idolo".
In 2011 he released his third solo album "Amador" and won the UFI award for "Best International Artist Of The Year".
In 2012 he produced the first solo (golden) album of León Larregui (Lead singer of the famous Mexican band "Zoé")
Adan starred in his father's film The Dance of Reality which was released in 2013.